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PAAR-like domain-containing protein
This domain is found at the N-terminal of bacterial toxin systems, including Tse7 (type IV secretion exported 7) from Pseudomonas aeruginosa, a type VI secretion exported toxin with DNase activity that induces growth arrest and ultimately DNA degradation within target cell [1]. The structure of this domain has a PAAR-like organisation necessary for interaction with T6SS VgrG tip and correct toxin delivery [1,2]. [1]. 30455305. The Pseudomonas aeruginosa T6SS-VgrG1b spike is topped by a PAAR protein eliciting DNA damage to bacterial competitors. Pissaridou P, Allsopp LP, Wettstadt S, Howard SA, Mavridou DAI, Filloux A;. Proc Natl Acad Sci U S A. 2018;115:12519-12524. [2]. 31993035. Redundancy and Specificity of Type VI Secretion vgrG Loci in Antibacterial Activity of Agrobacterium tumefaciens 1D1609 Strain. Santos MNM, Cho ST, Wu CF, Chang CJ, Kuo CH, Lai EM;. Front Microbiol. 2020;10:3004. (from Pfam)
DUF4150 domain-containing protein
DUF4150 domain-containing protein may belong to the proline-alanine-alanine-arginine (PAAR) repeat family; PAAR proteins are essential for type VI secretion system (T6SS)-mediated secretion
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