Protein Family Models

This family includes Schizosaccharomyces specific SAP domain containing proteins such as gene product new25 [1] . SAP ( SAF-A/B, Acinus and PIAS) motif is a DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins. For instance, the SAP domain of SUMO E3 ligase PIAS1 from human is shown to bind an A/T-rich DNA [2]. [1]. 21270388. Augmented annotation of the Schizosaccharomyces pombe genome reveals additional genes required for growth and viability. Bitton DA, Wood V, Scutt PJ, Grallert A, Yates T, Smith DL, Hagan IM, Miller CJ;. Genetics. 2011;187:1207-1217. [2]. 18831036. Solution structures and DNA binding properties of the N-terminal SAP domains of SUMO E3 ligases from Saccharomyces cerevisiae and Oryza sativa. Suzuki R, Shindo H, Tase A, Kikuchi Y, Shimizu M, Yamazaki T;. Proteins. 2009;75:336-347. (from Pfam)

Date:

2024-10-16

This domain of unknown function is found in uncharacterised proteins mainly from bacteria, but it is also found in eukaryotes. Some proteins containing this domain also contain zinc finger C2H2-type domains. There are three conserved motifs: TxI/V, RxFF and FxF, and a conserved W/Y residue at the C-terminal. (from Pfam)

Date:

2024-08-14