This domain has been shown to be part of the PUA superfamily [2]. This domain represents a general protein and polypeptide interaction domain for the ATP-dependent serine peptidase, LON, Peptidase_S16, Pfam:PF05362. ATP-dependent Lon proteases are conserved in all living organisms and catalyse rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. [1]. 16199667. Crystal structure of the N-terminal domain of E. coli Lon protease. Li M, Rasulova F, Melnikov EE, Rotanova TV, Gustchina A, Maurizi MR, Wlodawer A;. Protein Sci. 2005;14:2895-2900. [2]. 19191354. Structural genomics reveals EVE as a new ASCH/PUA-related domain. Bertonati C, Punta M, Fischer M, Yachdav G, Forouhar F, Zhou W, Kuzin AP, Seetharaman J, Abashidze M, Ramelot TA, Kennedy MA, Cort JR, Belachew A, Hunt JF, Tong L, Montelione GT, Rost B;. Proteins. 2009;75:760-773. [3]. 20834233. Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber. Cha SS, An YJ, Lee CR, Lee HS, Kim YG, Kim SJ, Kwon KK, De Donatis GM, Lee JH, Maurizi MR, Kang SG;. EMBO J. 2010;29:3520-3530. (from Pfam)
- Date:
- 2024-10-16