Protein Family Models

This domain is found at the N-terminus of proteins containing Pfam:PF13083 and Pfam:PF01424, including the jag proteins. (from Pfam)

Date:

2024-08-14

The K homology domain is a common RNA-binding motif present in one or multiple copies in both prokaryotic and eukaryotic regulatory proteins. These motifs may act cooperatively to bind RNA in the case of multiple motifs, or independently in the case of single KH motif proteins. The structure of the prokaryotic KH domain consists of a two-layer alpha/beta fold in the arrangement alpha/beta(2)/alpha/beta. This entry represents the KH domain from RNA-binding protein KhpA and KhpB (also known as Jag or EloR) [1]. KhpA is a single-KH domain protein while KhpB also has a Jag-N domain (Pfam:PF14804) of unknown function and a R3H domain (Pfam:PF01424) at the C-terminal [1]. [1]. 28941257. Absence of the KhpA and KhpB (JAG/EloR) RNA-binding proteins suppresses the requirement for PBP2b by overproduction of FtsA in Streptococcus pneumoniae D39. Zheng JJ, Perez AJ, Tsui HT, Massidda O, Winkler ME;. Mol Microbiol. 2017;106:793-814. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

Most bacterial proteins with this domain (R3H) at the C-terminus have a KH domain at the N-terminus plus additional regions of homology, and may be referred to as JAG (spoIIIJ Associated Gene), after proteins described in Bacillus subtilis and Streptococcus pneumoniae. The S. pneumoniae protein, a phosphoprotein, is also called RNA-binding cell elongation regulator EloR.

Date:

2024-10-16

Members of this family are nucleic acid-binding proteins (RNA or single-stranded DNA) with a KH domain at the N-terminus, an R3H domain at the C-terminus, and additional regions of homology. The founding member of this family was JAG (spoIIIJ Associated Gene) from Bacillus subtilis, but later work in other lineages, such as Streptococcus pneumoniae, as established a role in controlling cell elongation and the operation of the elongasome. The S. pneumoniae protein, a protein that undergoes regulatory phosphorylation and dephosphorylation, is also called RNA-binding cell elongation regulator EloR, and also KhpB.

Gene:

jag

Date:

2024-05-14

SpoIIIJ-associated protein jag is necessary for the third stage of sporulation

Date:

2018-12-13