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glutaredoxin family protein
These proteins are related to the Pfam:PF00462 family. This entry includes several viral glutaredoxins and many related bacterial and eukaryotic proteins of unknown function. The best characterised member is G4L (Swiss:P68460) from Vaccinia virus (strain Western Reserve/WR) (VACV), which is necessary for virion morphogenesis and replication [1]. This is a cytoplasmic protein which functions as a shuttle in a redox pathway between membrane-associated E10R and L1R or F9L [2]. [1]. 10982364. A glutaredoxin, encoded by the G4L gene of vaccinia virus, is essential for virion morphogenesis. White CL, Weisberg AS, Moss B;. J Virol. 2000;74:9175-9183. [2]. 11752136. Vaccinia virus G4L glutaredoxin is an essential intermediate of a cytoplasmic disulfide bond pathway required for virion assembly. White CL, Senkevich TG, Moss B;. J Virol. 2002;76:467-472. (from Pfam)
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