Protein Family Models

The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds. [1]. 8846223. Crystal structure of NADH oxidase from Thermus thermophilus. Hecht HJ, Erdmann H, Park HJ, Sprinzl M, Schmid RD. Nat Struct Biol 1995;2:1109-1114. [2]. 17331467. In silico identification of a new group of specific bacterial and fungal nitroreductases-like proteins. de Oliveira IM, Henriques JA, Bonatto D;. Biochem Biophys Res Commun. 2007;355:919-925. (from Pfam)

Date:

2024-10-16

nitroreductase family protein may catalyze the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles, requiring NAD(P)H as an electron donor in an obligatory two-electron transfer and using FMN as cofactor

Date:

2023-11-09