Protein Family Models for Protein (Select 1104385485) - Protein Family Models

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Items: 4

Select item 4231071.

TasA family protein

Members of this family include M73 family metalloproteases but also TasA, which is apparently enzymatically inactive and instead is the major secreted protein of Bacillus subtilis biofilm matrix.

Date:: 2024-08-14

Family Accession:: NF023806.5
Method:: HMM

Select item 4012272.

new record, indexing in progress

Family Accession:

Select item 3568723.

new record, indexing in progress

Family Accession:

Select item 1482924.

SipW-dependent-type signal peptide-containing protein

This HMM describes a protein N-terminal domain found regularly in proteins encoded near a variant form of signal peptidase I such as the SipW protein found in Bacillus subtilis but with homologs in endoplasmic reticulum and some archaea. Members of this family include camelysin (a casein-cleaving metalloprotease) and TasA (CotN), a metalloprotease that is secreted, along with extracellular polysaccharide (EPS), to be the major protein constituent of the Bacillus subtilis biofilm matrix. Sequencing from several known TasA/CotN proteins shows the cleavage location to be near the center of the alignment and typical of type I signal peptidases, with small residues at -3 and -1. This domain, therefore, appears to be a special subclass of signal peptide.