Protein Family Models for Protein (Select 1104416951) - Protein Family Models

Select item 4133971.

Platelet-activating factor acetylhydrolase, isoform II

Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2, responsible for inactivation of platelet-activating factor through cleavage of an acetyl group. Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, whose catalytic beta and gamma subunits are aligned in Pfam:PF02266, the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). This family aligns pPAF-AH and PAF-AH II, whose similarity was previously noted. [1]. 9645224. The structure and function of platelet-activating factor acetylhydrolases. Derewenda ZS, Derewenda U;. Cell Mol Life Sci 1998;54:446-455. [2]. 9218411. Platelet-activating factor acetylhydrolases. Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM;. J Biol Chem 1997;272:17895-17898. (from Pfam)

GO Terms:

Molecular Function:: 1-alkyl-2-acetylglycerophosphocholine esterase activity (GO:0003847)

Biological Process:: lipid catabolic process (GO:0016042)

Date:: 2024-11-04

Family Accession:: NF015368.5
Method:: HMM

Select item 4113292.

alpha/beta fold hydrolase

This catalytic domain is found in a very wide range of enzymes. [1]. 1409539. The alpha/beta hydrolase fold. Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag J, Sussman JL, Verschueren KHG, Goldman A;. Protein Eng 1992;5:197-211. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF012770.5
Method:: HMM

Select item 3900213.