Protein Family Models

This domain family is found in bacteria, and is approximately 50 amino acids in length. There are two completely conserved residues (Y and W) that may be functionally important. This family consists of leucine-rich repeat proteins involved in type III secretion. [1]. 10564523. Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems. Miao EA, Scherer CA, Tsolis RM, Kingsley RA, Adams LG, Baumler AJ, Miller SI;. Mol Microbiol. 1999;34:850-864. (from Pfam)

Date:

2024-10-16

CAUTION: This Pfam may not find all Leucine Rich Repeats in a protein. Leucine Rich Repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Review of LRR proteins. [1]. 7817399. The leucine-rich repeat: a versatile binding motif. Kobe B, Deisenhofer J;. Trends Biochem Sci 1994;19:415-421. 3D Structure of LRR from Porcine Ribonuclease Inhibitor. [2]. 8264799. Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. Kobe B, Deisenhofer J;. Nature 1993;366:751-756. (from Pfam)

Date:

2024-10-16