Protein Family Models

Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport [1]. [1]. 10694977. Analysis of the proteome of Mycobacterium tuberculosis in silico. Tekaia F, Gordon SV, Garnier T, Brosch R, Barrell BG, Cole ST;. Tuber Lung Dis 1999;79:329-342. (from Pfam)

Date:

2024-10-16

This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC [1]. SecD and SecF are required to maintain a proton motive force [2]. [1]. 9694879. SecDF of Bacillus subtilis, a molecular Siamese twin required for the efficient secretion of proteins. Bolhuis A, Broekhuizen CP, Sorokin A, van Roosmalen ML, Venema G, Bron S, Quax WJ, van Dijl JM;. J Biol Chem 1998;273:21217-21224. [2]. 8112309. SecD and SecF are required for the proton electrochemical gradient stimulation of preprotein translocation. Arkowitz RA, Wickner W;. EMBO J 1994;13:954-963. (from Pfam)

Date:

2024-10-16

Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer [1]. [1]. 12374972. Crystal structure of bacterial multidrug efflux transporter AcrB. Murakami S, Nakashima R, Yamashita E, Yamaguchi A;. Nature 2002;419:587-593. (from Pfam)

Date:

2024-10-16

efflux RND transporter permease subunit is an efflux protein similar to Escherichia coli multidrug export protein AcrF (acriflavine resistance protein F), part of the tripartite efflux system AcrEF-TolC that is involved in the efflux of indole and organic solvents

Date:

2021-02-05

Proteins scoring above the trusted cutoff (1000) form a tight clade within the RND (Resistance-Nodulation-Cell Division) superfamily. Proteins scoring greater than the noise cutoff (100) appear to form a larger clade, cleanly separated from more distant homologs that include cadmium/zinc/cobalt resistance transporters. This family is one of several subfamilies within the scope of Pfam HMM PF00873.

Date:

2024-06-24

Multidrug efflux RND transporter permease subunits that belong to this family include OqxB, AcrB, AcrD, AcrF, MdtF, AdeE, AdeJ, MexB, etc.

Date:

2022-10-11