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Family 4 Glycosyltransferase in conflict systems
This entry corresponds to Family 4 Glycosyltransferase domain comprised of two Rossmann fold subdomains. The domain is found in architecturally-rich proteins of metazoan counter-invader systems and in bacterial conflict systems [1]. [1]. 34061031. Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans. Kaur G, Iyer LM, Burroughs AM, Aravind L;. Elife. 2021; [Epub ahead of print] (from Pfam)
glycosyltransferase
Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family. (from Pfam)
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