Protein Family Models

FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum [1]. It appears to act as a hook-capping protein to enable assembly of hook protein subunits [1]. FlgD regulates the assembly of the hook cap structure to prevent leakage of hook monomers into the medium and hook monomer polymerisation and also plays a role in determination of the correct hook length, with the help of the FliK protein [2]. This family represents the N-terminal conserved region of FlgD. A recent crystal structure showed that this region was likely to be flexible and was cleaved off during crystallisation [3]. [1]. 8157595. FlgD is a scaffolding protein needed for flagellar hook assembly in Salmonella typhimurium. Ohnishi K, Ohto Y, Aizawa S, Macnab RM, Iino T;. J Bacteriol 1994;176:2272-2281. [2]. 19652342. Cloning, purification, crystallization and preliminary X-ray studies of flagellar hook scaffolding protein FlgD from Pseudomonas aeruginosa PAO1. Luo M, Niu S, Yin Y, Huang A, Wang D;. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009;65:795-797. [3]. 18599076. Crystal structure of the C-terminal domain of a flagellar hook-capping protein from Xanthomonas campestris. Kuo WT, Chin KH, Lo WT, Wang AH, Chou SH;. J Mol Biol. 2008;381:189-199. (from Pfam)

Date:

2024-10-16

Acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod

Gene:

flgD

Date:

2022-06-01

FlgD family protein similar to Bacillus subtilis FlaA locus uncharacterized protein YlxG

Date:

2018-03-24