This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex [1-6]. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel beta-sheet (middle/second) domain and a C-terminal alpha/beta-domain [4-7]. This is the beta domain which adopts a SH3-like barrel structure. [1]. 11296222. Structural and functional differences between two homologous mechanosensitive channels of Methanococcus jannaschii. Kloda A, Martinac B;. EMBO J 2001;20:1888-1896. [2]. 11159397. Molecular identification of a mechanosensitive channel in archaea. Kloda A, Martinac B;. Biophys J 2001;80:229-240. [3]. 11275684. Mechanosensitive channels in prokaryotes. Martinac B;. Cell Physiol Biochem 2001;11:61-76. [4]. 34376558. Mechanosensitive channel gating by delipidation. Flegler VJ, Rasmussen A, Borbil K, Boten L, Chen HA, Deinlein H, Halang J, Hellmanzik K, Loffler J, Schmidt V, Makbul C, Kraft C, Hedrich R, Rasmussen T, Bottcher B;. Proc Natl Acad Sci U S A. 2021; [Epub ahead of print]. [5]. 23012406. Conformational state of the MscS mechanosensitive channel in solution revealed by pulsed electron-electron double resonance (PELDOR) spectroscopy. Pliotas C, Ward R, Branigan E, Rasmussen A, Hagelueken G, Huang H, Black SS, Booth IR, Schiemann O, Naismith JH;. Proc Natl Acad Sci U S A. 2012;109:E2675-E2682. [6]. 23339071. Open and shut: crystal structures of the dodecylmaltoside solubilized mechanosensitive channel of small conductance from Escherichia coli and Helicobacter pylori at 4.4 A and 4.1 A resolutions. Lai JY, Poon YS, K. TRUNCATED at 1650 bytes (from Pfam)
GO Terms:- Date:
- 2024-10-16