A three-gene cassette encoding ImuA, ImuB, and ImuC ("inducible mutagenesis") is induced by DNA damage, is capable of DNA synthesis across DNA damage lesions, and consequently is associated with mutagenesis. This family, ImuA (previously misnamed SulA in Pseudomonas putida) shows some homology to SulA itself and to RecA. ImuB resembles Y-family polymerases but may be catalytically inactive. ImuC is a C-family polymerase, and catalytically active.
- Gene:
- imuA
GO Terms:- Biological Process:
- SOS response (GO:0009432)
- Biological Process:
- negative regulation of cell division (GO:0051782)
- Date:
- 2022-03-28