Protein Family Models

This winged helix domain is found in RNA-binding proteins such as CvfB [1]. [1]. 20399190. Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module. Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, Wilson IA;. Structure. 2010;18:537-547. (from Pfam)

Date:

2024-10-16

CvfB is a conserved regulatory protein important for the virulence of Staphylococcus aureus [1]. This entry represents the first of three S1-like OB-fold domains. Paper describing PDB structure 3go5. [1]. 20399190. Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module. Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, Wilson IA;. Structure. 2010;18:537-547. (from Pfam)

Date:

2024-10-16

This domain is found in the virulence regulatory factor CvfB from Streptococcus pneumoniae and in similar proteins predominantly found in Firmicutes. CvfB is composed of three consecutive S1 RNA-binding domains and a winged-helix (WH) domain (Pfam:PF17783). This entry represents the second S! domain, an RNA-binding module that adopts the typical S1 fold that consists of a five-stranded, antiparallel beta-sheet forming a beta-barrel [1]. Paper describing PDB structure 3go5. [1]. 20399190. Structure of a virulence regulatory factor CvfB reveals a novel winged helix RNA binding module. Matsumoto Y, Xu Q, Miyazaki S, Kaito C, Farr CL, Axelrod HL, Chiu HJ, Klock HE, Knuth MW, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Sekimizu K, Wilson IA;. Structure. 2010;18:537-547. (from Pfam)

Date:

2024-10-16

This HMM describes a variant form of the S1 domain, as found in the staphylococcal RNA-binding protein CvfB rather than 30S ribosomal protein S1 itself.

Date:

2024-08-14

S1 RNA-binding domain-containing protein similar to Staphylococcus aureus conserved virulence factor B (CvfB), which helps regulate proteins of the agr locus and facilitates production of factors thru an agr-independent pathway

Date:

2018-09-10