Protein Family Models

This domain is found in the stage II sporulation protein SpoIID. SpoIID is necessary for membrane migration as well as for some of the earlier steps in engulfment during bacterial endospore formation [2]. The domain is also found in amidase enhancer proteins. Amidases, like SpoIID, are cell wall hydrolases [1]. [1]. 10961456. Biological roles of two new murein hydrolases of Streptococcus pneumoniae representing examples of module shuffling. Lopez R, Gonzalez MP, Garcia E, Garcia JL, Garcia P;. Res Microbiol 2000;151:437-443. [2]. 12502745. A cytoskeleton-like role for the bacterial cell wall during engulfment of the Bacillus subtilis forespore. Abanes-De Mello A, Sun YL, Aung S, Pogliano K;. Genes Dev 2002;16:3253-3264. (from Pfam)

Date:

2024-10-16

SpoIID/LytB domain-containing protein similar to Bacillus subtilis stage II sporulation protein D (spoIID) that may act at the level of sigma-G activity or its stability

Date:

2019-06-07

This model describes a domain found typically in two or three proteins per genome in Cyanobacteria and Firmicutes, and sporadically in other genomes. One member is SpoIID of Bacillus subtilis. Another in B. subtilis is the C-terminal half of LytB, encoded immediately upstream of an amidase, the autolysin LytC, to which its N-terminus is homologous. Gene neighborhoods are not well conserved for members of this family, as many, such as SpoIID, are monocistronic. One early modelling-based study suggests a DNA-binding role for SpoIID, but the function of this domain is unknown.

Date:

2024-06-26