Protein Family Models

MntP is a family of bacterial proteins with a signal peptide and four transmembrane domains. It is a putative manganese efflux pump, since deletion of the gene leads to profound manganese sensitivity and elevated intracellular manganese levels in bacteria. Manganese is a highly important trace nutrient for organisms from bacteria to humans, and acts as an important element in the defence against oxidative stress and as an enzyme cofactor [1]. [1]. 21908668. The Escherichia coli MntR miniregulon includes genes encoding a small protein and an efflux pump required for manganese homeostasis. Waters LS, Sandoval M, Storz G;. J Bacteriol. 2011;193:5887-5897. (from Pfam)

Date:

2024-10-16

MntP/YtaF family protein similar to Escherichia coli MntP a putative manganese efflux pump and to Bacillus subtilis YtaF which is a membrane protein essential for sporulation

Date:

2020-08-05

This protein family was identified, at the time of the publication of the Carboxydothermus hydrogenoformans genome, as having a phylogenetic profile that exactly matches the subset of the Firmicutes capable of forming endospores. The species include Bacillus anthracis, Clostridium tetani, Thermoanaerobacter tengcongensis, Geobacillus kaustophilus, etc. This protein, previously named YtaF, is therefore a putative sporulation protein.

Gene:

ytaF

Date:

2024-08-07