Protein Family Models

This entry represents the alpha-helical domain from the Type VI secretion protein IcmF [1]. This domain is also found in the TssM protein where it forms part of the tip complex [1]. [1]. 26200339. Biogenesis and structure of a type VI secretion membrane core complex. Durand E, Nguyen VS, Zoued A, Logger L, Pehau-Arnaudet G, Aschtgen MS, Spinelli S, Desmyter A, Bardiaux B, Dujeancourt A, Roussel A, Cambillau C, Cascales E, Fronzes R;. Nature. 2015;523:555-560. (from Pfam)

Date:

2024-10-16

This domain is found in bacterial IcmF (intracellular multiplication and human macrophage-killing) proteins. It is found to the N-terminus of the IcmF-related domain, Pfam:PF06761. (from Pfam)

Date:

2024-08-14

This family represents a conserved region within several bacterial proteins that resemble IcmF, which has been proposed [1] to be involved in Vibrio cholerae cell surface reorganisation, resulting in increased adherence to epithelial cells and increased conjugation frequency. Note that many family members are hypothetical proteins. [1]. 12127983. Involvement of in vivo induced icmF gene of Vibrio cholerae in motility, adherence to epithelial cells, and conjugation frequency. Das S, Chakrabortty A, Banerjee R, Chaudhuri K;. Biochem Biophys Res Commun 2002;295:922-928. (from Pfam)

Date:

2024-10-16

IcmF_C family represents a conserved region situated towards the C-terminal end of IcmF-like proteins. It was thought to be involved in Vibrio cholerae cell surface reorganisation that results in increased adherence to epithelial cells leading to an increased conjugation frequency [1]. IcmF as a whole interacts with DotU whereby these bind tightly and form the docking area of the T6SS within the inner membrane. The exact function of this domain is not clear [2]. [1]. 12127983. Involvement of in vivo induced icmF gene of Vibrio cholerae in motility, adherence to epithelial cells, and conjugation frequency. Das S, Chakrabortty A, Banerjee R, Chaudhuri K;. Biochem Biophys Res Commun 2002;295:922-928. [2]. 24381728. The rise of the Type VI secretion system. Filloux A;. F1000Prime Rep. 2013;5:52. (from Pfam)

Date:

2024-10-16

TssM, a member of the IcmF family, is a type VI secretion system (T6SS) membrane subunit. It is related to, although distinct from, IcmF, which appears in type IV secretion systems (T4SS).

Gene:

tssM

Date:

2024-08-07