Protein Family Models

This domain is found to the N-terminus of the Pfam:PF01432 domain in bacterial and archaeal proteins including Oligoendopeptidase F. An example of this protein is Lactococcus lactis PepF [1]. [1]. 7798200. Biochemical and genetic characterization of PepF, an oligopeptidase from Lactococcus lactis. Monnet V, Nardi M, Chopin A, Chopin MC, Gripon JC;. J Biol Chem 1994;269:32070-32076. (from Pfam)

Date:

2024-10-16

This is the Thimet oligopeptidase family, large family of mammalian and bacterial oligopeptidases that cleave medium sized peptides. The group also contains mitochondrial intermediate peptidase which is encoded by nuclear DNA but functions within the mitochondria to remove the leader sequence. [1]. 7674922. Evolutionary families of metallopeptidases. Rawlings ND, Barrett AJ;. Meth Enzymol 1995;248:183-228. (from Pfam)

Date:

2024-10-16

The M3 family of metallopeptidases contains several distinct clades. Oligoendopeptidase F as characterized in Lactococcus, the functionally equivalent oligoendopeptidase B of group B Streptococcus, and closely related sequences are described by TIGR00181. The present family is quite similar but forms a distinct clade, and a number of species have one member of each. A greater sequence difference separates members of TIGR02289, probable oligoendopeptidases of the M3 family that probably should not be designated PepF.

Date:

2019-09-10

M3 family oligoendopeptidase similar to oligoendopeptidase F (PepF) that hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad specificity

Date:

2023-02-27