Protein Family Models

T6SS_VasJ is a family from Gram-negative bacteria that forms a component of the type VI pathogenic secretion system. In the case of the Escherichia coli RS218 strain UniProtKB:G8IRL4, EvfF,it represents expression of the full-length gene; whereas it is just the C-terminal part of EvfE, UniProtKB:G8IRL3. The N-terminal part of these sequences is in family ImpA_N, Pfam:PF06812 [1,2]. [1]. 182899. Fc receptor-mediated inhibition of murine B-lymphocyte activation. Ryan JL, Henkart PA;. J Exp Med. 1976;144:768-775. [2]. 22184413. Hcp family proteins secreted via the type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Zhou Y, Tao J, Yu H, Ni J, Zeng L, Teng Q, Kim KS, Zhao GP, Guo X, Yao Y;. Infect Immun. 2012;80:1243-1251. (from Pfam)

Date:

2024-10-16

This family represents a conserved region located towards the N-terminal end of ImpA and related proteins. ImpA is an inner membrane protein, which has been suggested to be involved with proteins that are exported and associated with colony variations in Actinobacillus actinomycetemcomitans [1]. The ImpA gene in Vibrio cholera and many other bacteria is expressed from the virulence factor operon which produces the pathogenic injection, type VI secretion system; although the exact function of this gene-product is not known it appears to be an essential component of the pathogenic effect. [1]. 11083768. impA, a gene coding for an inner membrane protein, influences colonial morphology of Actinobacillus actinomycetemcomitans. Mintz KP, Fives-Taylor PM;. Infect Immun 2000;68:6580-6586. [2]. 16432199. Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system. Pukatzki S, Ma AT, Sturtevant D, Krastins B, Sarracino D, Nelson WC, Heidelberg JF, Mekalanos JJ;. Proc Natl Acad Sci U S A. 2006;103:1528-1533. (from Pfam)

Date:

2024-10-16

This HMM describes one of two major forms of type VI secretion apparatus protein called TssA. The other form, similar primarily in the N-terminal region, is described by TIGR03363.

Gene:

tssA

Date:

2019-09-10

TssA family type VI secretion system protein functions in protein translocation and is involved in the pathogenicity of bacteria

Date:

2021-05-21