Protein Family Models

This entry represents the N-terminal domain of DsbD, a transmembrane electron transporter [1-3]. DsbD binds to a DsbC dimer and selectively activates it using electrons from the cytoplasm. The N-terminal domain of DsbD (DsbDN) is capable of forming disulfides with oxidized DsbC, DsbE, or DsbG as well as with reduced DsbD [1-3]. [1]. 12033924. Thiol-disulfide exchange in an immunoglobulin-like fold: structure of the N-terminal domain of DsbD. Goulding CW, Sawaya MR, Parseghian A, Lim V, Eisenberg D, Missiakas D;. Biochemistry. 2002;41:6920-6927. [2]. 29372905. Production, biophysical characterization and initial crystallization studies of the N- and C-terminal domains of DsbD, an essential enzyme in Neisseria meningitidis. Smith RP, Whitten AE, Paxman JJ, Kahler CM, Scanlon MJ, Heras B;. Acta Crystallogr F Struct Biol Commun. 2018;74:31-38. [3]. 32305461. Protein Disulfide Exchange by the Intramembrane Enzymes DsbB, DsbD, and CcdA. Bushweller JH;. J Mol Biol. 2020;432:5091-5103. (from Pfam)

Date:

2024-10-16