Protein Family Models

This presumed domain is functionally uncharacterised. This domain is found in bacteria, eukaryotes and viruses. This domain is typically between 174 to 190 amino acids in length. This domain has a single completely conserved residue G that may be functionally important. (from Pfam)

Date:

2024-08-14

This short domain is found in many different glycosyl hydrolase enzymes, representing the carbohydrate-binding module family 5/12, including proteins such as chitinase A1, chitinase B, and endoglucanase. The domain has a carbohydrate-binding function and contains six aromatic groups that may be important for binding. These modules have a core structure consisting of a 3-stranded meander beta-sheet [1-5]. [1]. 10788483. Solution structure of the chitin-binding domain of Bacillus circulans WL-12 chitinase A1. Ikegami T, Okada T, Hashimoto M, Seino S, Watanabe T, Shirakawa M;. J Biol Chem. 2000;275:13654-13661. Paper describing PDB structure 1wvu. [2]. 16516924. Structural studies of a two-domain chitinase from Streptomyces griseus HUT6037. Kezuka Y, Ohishi M, Itoh Y, Watanabe J, Mitsutomi M, Watanabe T, Nonaka T;. J Mol Biol. 2006;358:472-484. Paper describing PDB structure 2d49. [3]. 16567413. Identification of the substrate interaction region of the chitin-binding domain of Streptomyces griseus chitinase C. Akagi K, Watanabe J, Hara M, Kezuka Y, Chikaishi E, Yamaguchi T, Akutsu H, Nonaka T, Watanabe T, Ikegami T;. J Biochem. 2006;139:483-493.DR CAZY; CBM5;. Paper describing PDB structure 2rts. [4]. 24272751. Solution structure of the chitin-binding domain 1 (ChBD1) of a hyperthermophilic chitinase from Pyrococcus furiosus. Mine S, Nakamura T, Sato T, Ikegami T, Uegaki K;. J Biochem. 2014;155:115-122. [5]. 25479092. Structure-based analysis of domain function of chitin oligosaccharide deacetylase from Vibrio parahaemolyticus. Hirano T, Sugiyama K, Sakaki Y, Hakamata W, Park SY, Nishio T;. FEBS Lett. 2015;589:145-15. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-16

This family is the putative binding domain for the substrates of enhancin, and other similar metallopeptidases. This is not the enzymically active, peptidase, part of the proteins - see Pfam:PF13402. [1]. 9192677. An intestinal mucin is the target substrate for a baculovirus enhancin. Wang P, Granados RR;. Proc Natl Acad Sci U S A 1997;94:6977-6982. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14