Protein Family Models

A domain of unknown function found in multiple copies in several archaebacterial proteins. Conserved N-terminal lysine and C-terminal asparagine with central asp/glu suggests that many of these domain may contain an isopeptide bond. In Methanothermobacter sp. CaT2, a DUF11-containing repeat hypothetical protein encoded by MTCT_1020 plays a key role as a membrane-bound adhesion protein in the aggregation of CaT2. DUF11-containing repeat domains are not involved in aggregation, but may be important for stabilizing the surface cell wall structures of CaT2 [1]. [1]. 31189768. An Aggregation-defective Mutant of Methanothermobacter sp. CaT2 Reveals Unique Protein-dependent Aggregation. Sumikawa K, Kosaka T, Mayahara N, Matsutani M, Udo K, Yamada M;. Microbes Environ. 2019;34:244-251. (from Pfam)

Date:

2024-10-16

This model represents the conserved region of about 53 amino acids shared between regions, usually repeated, of proteins from a small number of phylogenetically diverse prokaryotes. The model overlaps significantly in coverage with DUF11 (PF01345). Examples of the domain occur within longer repeats in three of the five longest proteins of Bacillus anthracis, in a 131-residue repeat in a cell wall-anchored protein of Enterococcus faecalis, and a 120-residue repeat in Methanobacterium thermoautotrophicum. A similar region is found in some Chlamydial outer membrane proteins.

Date:

2021-07-15