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metallophosphoesterase family protein
Members of this family are part of the Calcineurin-like phosphoesterase superfamily. [1]. 9685491. Phosphoesterase domains associated with DNA polymerases of diverse origins. Aravind L, Koonin EV;. Nucleic Acids Res 1998;26:3746-3752. (from Pfam)
metallophosphoesterase
metallophosphoesterase contains an active site consisting of two metal ions (usually manganese, iron, or zinc)
YfcE family phosphodiesterase
Members of this largely uncharacterized family share a motif approximating DXH(X25)GDXXD(X25)GNHD as found in several phosphoesterases, including the nucleases SbcD and Mre11, and a family of uncharacterized archaeal putative phosphoesterases described by TIGR00024. In this family, the His residue in GNHD portion of the motif is not conserved. The member MJ0936, one of two from Methanococcus jannaschii, was shown (PMID:15128743) to act on model phosphodiesterase substrates; a divalent cation was required.
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