Protein Family Models for Protein (Select 1267517911) - Protein Family Models

Select item 4236481.

This presumed domain is found at the C-terminus of proteins that contain a transglutaminase core domain. The function of this domain is unknown. The domain has a conserved TXXE motif. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024948.5
Method:: HMM

Select item 4215912.

transglutaminaseTgpA domain-containing protein

This domain can be found at the N terminus of TgpA from Pseudomonas aeruginosa. TgpA is a transglutaminase that plays a critical role in the viability of Pseudomonas aeruginosa [1,2]. This domain is composed of 5 transmembrane helices [2]. [1]. 23209712. TgpA, a protein with a eukaryotic-like transglutaminase domain, plays a critical role in the viability of Pseudomonas aeruginosa. Milani A, Vecchietti D, Rusmini R, Bertoni G;. PLoS One. 2012;7:e50323. [2]. 30599211. Structural and functional characterization of TgpA, a critical protein for the viability of Pseudomonas aeruginosa. Uruburu M, Mastrangelo E, Bolognesi M, Ferrara S, Bertoni G, Milani M;. J Struct Biol. 2019;205:18-25. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF023418.5
Method:: HMM

Select item 4126103.

transglutaminase domain-containing protein

This family includes animal transglutaminases and other bacterial proteins of unknown function. Sequence conservation in this superfamily primarily involves three motifs that centre around conserved cysteine, histidine, and aspartate residues that form the catalytic triad in the structurally characterised transglutaminase, the human blood clotting factor XIIIa' [1]. On the basis of the experimentally demonstrated activity of the Methanobacterium phage pseudomurein endoisopeptidase [2], it is proposed that many, if not all, microbial homologues of the transglutaminases are proteases and that the eukaryotic transglutaminases have evolved from an ancestral protease. [3] [1]. 7913750. Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII. Yee VC, Pedersen LC, Le Trong I, Bishop PD, Stenkamp RE, Teller DC;. Proc Natl Acad Sci USA 1994;91:7296-7300. [2]. 9791169. Molecular analysis of Methanobacterium phage psiM2. Pfister P, Wasserfallen A, Stettler R, Leisinger T;. Mol Microbiol 1998;30:233-244. [3]. 10452618. A superfamily of archaeal, bacterial, and eukaryotic proteins homologous to animal transglutaminases [In Process Citation]. Makarova KS, Aravind L, Koonin EV;. Protein Sci 1999;8:1714-1719. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF013961.5
Method:: HMM

Select item 4004924.