Protein Family Models

This entry represents a predicted sensor domain in bacterial NACHT conflict systems. It is likely to bind a ligand which could contribute to activation of enzymatic domains additionally fused to the N-terminus of the NACHT module [1]. [1]. 37160116. Bacterial NLR-related proteins protect against phage. Kibby EM, Conte AN, Burroughs AM, Nagy TA, Vargas JA, Whalen LA, Aravind L, Whiteley AT;. Cell. 2023;186:2410-2424. (from Pfam)

Date:

2024-10-16

Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2] [1]. 1650347. Characterization and expression of the Escherichia coli Mrr restriction system. Waite-Rees PA, Keating CJ, Moran LS, Slatko BE, Hornstra LJ, Benner JS;. J Bacteriol 1991;173:5207-5219. [2]. 11313145. Identification of a PD-(D/E)XK-like domain with a novel configuration of the endonuclease active site in the methyl-directed restriction enzyme Mrr and its homologs. Bujnicki JM, Rychlewski L;. Gene 2001;267:183-191. (from Pfam)

Date:

2024-10-16

Prokaryotic family found in type II restriction enzymes containing the hallmark (D/E)-(D/E)XK active site. Presence of catalytic residues implicates this region in the enzymatic cleavage of DNA [1,2]. [1]. 1650347. Characterization and expression of the Escherichia coli Mrr restriction system. Waite-Rees PA, Keating CJ, Moran LS, Slatko BE, Hornstra LJ, Benner JS;. J Bacteriol 1991;173:5207-5219. [2]. 11313145. Identification of a PD-(D/E)XK-like domain with a novel configuration of the endonuclease active site in the methyl-directed restriction enzyme Mrr and its homologs. Bujnicki JM, Rychlewski L;. Gene 2001;267:183-191. (from Pfam)

Date:

2024-10-16

DNA modification-dependent restriction endonuclease similar to Mycobacterium MspJI and Azoarcus AspBHI

Date:

2017-02-03