Protein Family Models

Members of this family usually also match to Pfam:PF00330. This domain undergoes conformational change in the enzyme mechanism [1]. [1]. 7675781. Steric and conformational features of the aconitase mechanism. Lauble H, Stout CD;. Proteins 1995;22:1-11. (from Pfam)

Date:

2024-10-16

Members of this family include aconitase (aconitate hydratase), 3-isopropylmalate dehydratase, and homoaconitase.

Date:

2024-08-14

Catalyzes the conversion of citrate to isocitrate

Gene:

acnA

Date:

2020-10-26

This HMM represents one form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It is found in bacteria, archaea, and eukaryotic cytosol. It has been shown to act also as an iron-responsive element binding protein in animals and may have the same role in other eukaryotes.

Gene:

acnA

Date:

2021-04-27

Members of this family appear in an operon for the degradation of propionyl-CoA via 2-methylcitrate. This family is homologous to aconitases A and B and appears to act the part as 2-methylisocitrate dehydratase, the enzyme after PrpD and before PrpB. In Escherichia coli, which lacks a member of this family, 2-methylisocitrate dehydratase activity was traced to aconitase B (TIGR00117) (PMID:12473114).

Gene:

acnD

Date:

2024-06-24

Catalyzes the conversion of citrate to isocitrate

Gene:

acnA

Date:

2021-03-12