Protein Family Models for Protein (Select 1339788559) - Protein Family Models

Select item 4226821.

This family contains proteins with N-acetyltransferase functions. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024871.5
Method:: HMM

Select item 4144602.

FemAB_like is a family of both baterial and Viridiplantae proteins with responsibility for building interpeptide bridges in peptidoglycan. Such a function is feasible for bacteria but less likely for the plant members of this family. Perhaps the plant-members are using homologous proteins to recognise bacterial peptidoglcans as part of their innate immune system [1]. [1]. 20537955. The challenge of annotating protein sequences: The tale of eight domains of unknown function in Pfam. Goonesekere NC, Shipely K, O'Connor K;. Comput Biol Chem. 2010;34:210-214. (from Pfam)

Date:: 2024-10-16

Family Accession:: NF016242.5
Method:: HMM

Select item 4131943.

peptidoglycan bridge formation glycyltransferase FemA/FemB family protein

The femAB operon codes for two nearly identical approximately 50-kDa proteins involved in the formation of the Staphylococcal pentaglycine interpeptide bridge in peptidoglycan [1]. These proteins are also considered as a factor influencing the level of methicillin resistance [2]. [1]. 9393725. Specificities of FemA and FemB for different glycine residues: FemB cannot substitute for FemA in staphylococcal peptidoglycan pentaglycine side chain formation. Ehlert K, Schroder W, Labischinski H;. J Bacteriol 1997;179:7573-7576. [2]. 10209768. Molecular characterization of femA from Staphylococcus hominis and Staphylococcus saprophyticus, and femA-based discrimination of staphylococcal species. Vannuffel P, Heusterspreute M, Bouyer M, Vandercam B, Philippe M, Gala JL;. Res Microbiol 1999;150:129-141. [3]. 2559314. FemA, a host-mediated factor essential for methicillin resistance in Staphylococcus aureus: molecular cloning and characterization. Berger-Bachi B, Barberis-Maino L, Strassle A, Kayser FH;. Mol Gen Genet 1989;219:263-269. [4]. 8981974. Cell wall monoglycine cross-bridges and methicillin hypersusceptibility in a femAB null mutant of methicillin-resistant Staphylococcus aureus. Stranden AM, Ehlert K, Labischinski H, Berger-Bachi B;. J Bacteriol 1997;179:9-16. [5]. 8383661. Influence of femB on methicillin resistance and peptidoglycan metabolism in Staphylococcus aureus. Henze U, Sidow T, Wecke J, Labischinski H, Berger-Bachi B;. J Bacteriol 1993;175:1612-1620. (from Pfam)

GO Terms:

Molecular Function:: aminoacyltransferase activity (GO:0016755)

Biological Process:: cell wall macromolecule biosynthetic process (GO:0044038)

Date:: 2024-10-16

Family Accession:: NF014445.5
Method:: HMM

Select item 3994784.