Protein Family Models

This family contains a diverse range of predicted transporter proteins. Including the DctM subunit of the bacterial and archaeal TRAP C4-dicarboxylate transport (Dct) system permease. In general, C4-dicarboxylate transport systems allow C4-dicarboxylates like succinate, fumarate, and malate to be taken up. TRAP C4-dicarboxylate carriers are secondary carriers that use an electrochemical H+ gradient as the driving force for transport. DctM is an integral membrane protein that is one of the constituents of TRAP carriers [1]. Note that many family members are hypothetical proteins. [1]. 11803016. C4-dicarboxylate carriers and sensors in bacteria. Janausch IG, Zientz E, Tran QH, Kroger A, Unden G;. Biochim Biophys Acta 2002;1553:39-56. (from Pfam)

Date:

2024-10-16

Tripartite ATP-independent periplasmic (TRAP) transporter large permease subunit is the membrane component of a TRAP tranporter, a substrate-binding protein (SBP)-dependent secondary transporter with similarity to C4-dicarboxylate TRAP transporter permease protein DctM

Date:

2024-05-18

The Tripartite ATP-independent Periplasmic Transporter (TRAP-T) Family (TC 2.A.56)- DctM subunit TRAP-T family permeases generally consist of three components, and these systems have so far been found in Gram-negative bacteria, Gram-postive bacteria and archaea. Only one member of the family has been both sequenced and functionally characterized. This system is the DctPQM system of Rhodobacter capsulatus (Forward et al., 1997). DctP is a periplasmic dicarboxylate (malate, fumarate, succinate) binding receptor that is biochemically well-characterized. DctQ is an integral cytoplasmic membrane protein with 4 putative transmembrane a-helical spanners (TMSs). DctM is a second integral cytoplasmic membrane protein with 12 putative TMSs. These proteins have been shown to be both necessary and sufficient for the proton motive force-dependent uptake of dicarboxylates into R. capsulatus.

Date:

2024-06-14