Protein Family Models

Rpb6 is an essential subunit in the eukaryotic polymerases Pol I, II and III. This family also contains the bacterial equivalent to Rpb6, the omega subunit. Rpb6 and omega are structurally conserved and both function in polymerase assembly [1]. [1]. 11158566. Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly. Minakhin L, Bhagat S, Brunning A, Campbell EA, Darst SA, Ebright RH, Severinov K;. Proc Natl Acad Sci U S A 2001;98:892-897. [2]. 16908155. The evolving story of the omega subunit of bacterial RNA polymerase. Mathew R, Chatterji D;. Trends Microbiol. 2006;14:450-455. (from Pfam)

Date:

2024-10-16

DNA-directed RNA polymerase subunit omega promotes RNA polymerase assembly by latching the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits

Date:

2017-12-01

This small component of highly purified E. coli RNA polymerase is not required for transcription, but acts in assembly and is present in stochiometric amounts. The trusted cutoff excludes archaeal homologs but captures some organellar sequences.

Gene:

rpoZ

Date:

2024-06-27