U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Links from Protein

Items: 11

1.

C-terminal domain of 1-Cys peroxiredoxin

This is the C-terminal domain of 1-Cys peroxiredoxin (1-cysPrx), a member of the peroxiredoxin superfamily which protect cells against membrane oxidation through glutathione (GSH)-dependent reduction of phospholipid hydroperoxides to corresponding alcohols [1]. The C-terminal domain is crucial for providing the extra cysteine necessary for dimerisation of the whole molecule. Loss of the enzyme's peroxidase activity is associated with oxidation of the catalytic cysteine, upstream of this domain; and glutathionylation, presumably through its disruption of protein structure, facilitates access for GSH, resulting in spontaneous reduction of the mixed disulfide to the sulfhydryl and consequent activation of the enzyme [2]. The domain is associated with family AhpC-TSA, Pfam:PF00578, which carries the catalytic cysteine. [1]. 9587003. Crystal structure of a novel human peroxidase enzyme at 2.0 A. resolution.. Choi HJ, Kang SW, Yang CH, Rhee SG, Ryu SE;. Nat Struct Biol. 1998;5:400-406.. [2]. 15004285. Activation of the antioxidant enzyme 1-CYS peroxiredoxin. requires glutathionylation mediated by heterodimerization with. pi GST.. Manevich Y, Feinstein SI, Fisher AB;. Proc Natl Acad Sci U S A. 2004;101:3780-3785. (from Pfam)

GO Terms:
Molecular Function:
peroxiredoxin activity (GO:0051920)
Date:
2024-08-14

Family Accession:
NF021902.5
Method:
HMM

2.

redoxin family protein

This family of redoxins includes peroxiredoxin, thioredoxin and glutaredoxin proteins. (from Pfam)

GO Terms:
Molecular Function:
oxidoreductase activity (GO:0016491)
Date:
2024-08-14

Family Accession:
NF020123.5
Method:
HMM

3.

redoxin domain-containing protein

This family contains proteins related to alkyl hydroperoxide reductase (AhpC) and thiol specific antioxidant (TSA). [1]. 8041738. Cloning and sequencing of thiol-specific antioxidant from. mammalian brain: alkyl hydroperoxide reductase and. thiol-specific antioxidant define a large family of antioxidant. enzymes.. Chae HZ, Robison K, Poole LB, Church G, Storz G, Rhee SG;. Proc Natl Acad Sci U S A 1994;91:7017-7021. (from Pfam)

GO Terms:
Molecular Function:
antioxidant activity (GO:0016209)
Molecular Function:
oxidoreductase activity (GO:0016491)
Date:
2024-08-14

Family Accession:
NF012787.5
Method:
HMM

4.
new record, indexing in progress
Family Accession:
5.
new record, indexing in progress
Family Accession:
6.
new record, indexing in progress
Family Accession:
7.
new record, indexing in progress
Family Accession:
8.
new record, indexing in progress
Family Accession:
9.
new record, indexing in progress
Family Accession:
10.

peroxiredoxin

Alkyl hydroperoxidase; catalyze the reduction of hydrogen peroxide to water and the reduction of alkyl hydroperoxides to the corresponding alcohols

GO Terms:
Molecular Function:
thioredoxin peroxidase activity (GO:0008379)
Molecular Function:
peroxiredoxin activity (GO:0051920)
Biological Process:
cellular oxidant detoxification (GO:0098869)
Date:
2021-08-12

Family Accession:
NF009668.0
Method:
HMM

11.

peroxiredoxin

peroxiredoxin is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively

Date:
2022-11-09

Family Accession:
10122448
Method:
Sparcle

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Filter your results:

Find related data

Recent activity

Clear Turn Off Turn On

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
You are here: NCBI
Support Center