Protein Family Models

This entry represents the glycoside hydrolase domain found at the C-terminal of Mannosylglycerate hydrolase MGH1 and similar sequences. Paper describing PDB structure 1v7v. [1]. 15274915. Chitobiose phosphorylase from Vibrio proteolyticus, a member of glycosyl transferase family 36, has a clan GH-L-like (alpha/alpha)(6) barrel fold. Hidaka M, Honda Y, Kitaoka M, Nirasawa S, Hayashi K, Wakagi T, Shoun H, Fushinobu S;. Structure. 2004;12:937-947. Paper describing PDB structure 2jf4. [2]. 17455176. Molecular basis for trehalase inhibition revealed by the structure of trehalase in complex with potent inhibitors. Gibson RP, Gloster TM, Roberts S, Warren RA, Storch de Gracia I, Garcia A, Chiara JL, Davies GJ;. Angew Chem Int Ed Engl. 2007;46:4115-4119. Paper describing PDB structure 2okx. [3]. 17936784. Crystal structure of glycoside hydrolase family 78 alpha-L-Rhamnosidase from Bacillus sp. GL1. Cui Z, Maruyama Y, Mikami B, Hashimoto W, Murata K;. J Mol Biol. 2007;374:384-398. Paper describing PDB structure 3d3i. [4]. 18586271. Structural insights into the substrate specificity and function of Escherichia coli K12 YgjK, a glucosidase belonging to the glycoside hydrolase family 63. Kurakata Y, Uechi A, Yoshida H, Kamitori S, Sakano Y, Nishikawa A, Tonozuka T;. J Mol Biol. 2008;381:116-128. Paper describing PDB structure 3qde. [5]. 22102229. Structure of cellobiose phosphorylase from Clostridium thermocellum in complex with phosphate. Bianchetti CM, Elsen NL, Fox BG, Phillips GN Jr;. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011;67:1345-1349. [6]. 28329766. Complex pectin metabolism by gut bacteria reveals novel catalyti. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-10-21

This family consists of bacterial rhamnosidase A and B enzymes. L-Rhamnose is abundant in biomass as a common constituent of glycolipids and glycosides, such as plant pigments, pectic polysaccharides, gums or biosurfactants. Some rhamnosides are important bioactive compounds. For example, terpenyl glycosides, the glycosidic precursor of aromatic terpenoids, act as important flavouring substances in grapes. Other rhamnosides act as cytotoxic rhamnosylated terpenoids, as signal substances in plants or play a role in the antigenicity of pathogenic bacteria [1]. [1]. 10632887. The thermostable alpha-L-rhamnosidase RamA of Clostridium stercorarium: biochemical characterization and primary structure of a bacterial alpha-L-rhamnoside hydrolase, a new type of inverting glycoside hydrolase. Zverlov VV, Hertel C, Bronnenmeier K, Hroch A, Kellermann J, Schwarz WH;. Mol Microbiol 2000;35:173-179. (from Pfam)

Date:

2024-10-16

This domain is found on the N-terminal of some glycogen debranching enzymes and is usually followed by the GDE_C (PF06202) and in this sense it is analogous (but probably not homologous) to the GDE_N (PF12439). Its exact function is unknown (from Pfam)

Date:

2024-08-14

This family includes human glycogen branching enzyme Swiss:P35573. This enzyme contains a number of distinct catalytic activities. It has been shown for the yeast homologue Swiss:O93808 that mutations in this region disrupt the enzymes Amylo-alpha-1,6-glucosidase (EC:3.2.1.33). [1]. 11375985. Identification of the catalytic residues of bifunctional glycogen debranching enzyme. Nakayama A, Yamamoto K, Tabata S;. J Biol Chem 2001;276:28824-28828. (from Pfam)

Date:

2024-10-16

amylo-alpha-1,6-glucosidase catalyzes the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin and with 4-alpha-D-glucanotransferase, constitute a glycogen debranching enzyme

Date:

2021-02-01