Protein Family Models

Members of this family, named YmfI after the founding member from Bacillus subtilis, are restricted to bacterial species in which the post-translational modification of elongation factor P (EF-P) is 5-aminopentanol at Lys-32. This protein, a homolog of the 3-keto-acyl ACP reductase FabG, reduces EF-P 5-aminopentanone to EF-P 5-aminopentanol. All 427 members of the seed alignment are from species in which YmfF and YmfH homologs are encoded by an adjacent gene pair.

Gene:

ymfI

Date:

2024-08-06

This domain is found in Enoyl-(Acyl carrier protein) reductases. (from Pfam)

Date:

2024-08-14

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group [1]. [1]. 23790488. Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene. Bonnett SA, Whicher JR, Papireddy K, Florova G, Smith JL, Reynolds KA;. Chem Biol. 2013;20:772-783. (from Pfam)

Date:

2024-10-16

This family contains a wide variety of dehydrogenases. [1]. 9735295. The refined crystal structure of Drosophila lebanonensis alcohol dehydrogenase at 1.9 A resolution. Benach J, Atrian S, Gonzalez-Duarte R, Ladenstein R;. J Mol Biol 1998;282:383-399. [2]. 10387002. Structure of tropinone reductase-II complexed with NADP+ and pseudotropine at 1.9 A resolution: implication for stereospecific substrate binding and catalysis. Yamashita A, Kato H, Wakatsuki S, Tomizaki T, Nakatsu T, Nakajima K, Hashimoto T, Yamada Y, Oda J;. Biochemistry 1999;38:7630-7637. (from Pfam)

Date:

2024-10-16

Date:

2021-07-21

Gene:

fabG

Date:

2021-07-30