Protein Family Models

Members of this family are dipeptidyl carboxydipeptidases (cleave carboxyl dipeptides) and most notably convert angiotensin I to angiotensin II. Many members of this family contain a tandem duplication of the 600 amino acid peptidase domain, both of these are catalytically active. Most members are secreted membrane bound ectoenzymes. [1]. 9629165. Toward a role for angiotensin-converting enzyme in insects. Isaac RE, Schoofs L, Williams TA, Corvol P, Veelaert D, Sajid M, Coates D;. Ann N Y Acad Sci 1998;839:288-292. [2]. 7674927. Peptidyl dipeptidase A: angiotensin I-converting enzyme. Corvol P, Williams TA, Soubrier F;. Methods Enzymol 1995;248:283-305. (from Pfam)

Date:

2024-10-16

M2 family metallopeptidase similar to angiotensin converting enzyme (ACE), a zinc-dependent dipeptidyl carboxypeptidase

Date:

2019-02-27