Protein Family Models

This entry corresponds to the N-terminal alpha helical domain of the HemK protein. HemK is a methyltransferase enzyme that carries out the methylation of the N5 nitrogen of the glutamine found in the conserved GGQ motif of class-1 release factors [3]. [1]. 15223314. Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase. Yang Z, Shipman L, Zhang M, Anton BP, Roberts RJ, Cheng X;. J Mol Biol. 2004;340:695-706. [2]. 16364916. Molecular basis for bacterial class I release factor methylation by PrmC. Graille M, Heurgue-Hamard V, Champ S, Mora L, Scrima N, Ulryck N, van Tilbeurgh H, Buckingham RH;. Mol Cell. 2005;20:917-927. [3]. 12741815. Structures along the catalytic pathway of PrmC/HemK, an N5-glutamine AdoMet-dependent methyltransferase. Schubert HL, Phillips JD, Hill CP;. Biochemistry. 2003;42:5592-5599. [4]. 18247349. A novel mode of dimerization via formation of a glutamate anhydride crosslink in a protein crystal structure. Agarwal R, Burley SK, Swaminathan S;. Proteins. 2008;71:1038-1041. (from Pfam)

Date:

2024-10-16

This family appears to have methyltransferase activity. (from Pfam)

Date:

2024-08-14

This family appears to be a methyltransferase domain. (from Pfam)

Date:

2024-08-14

Members of this family are SAM dependent methyltransferases. (from Pfam)

Date:

2024-08-14

This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences. [1]. 8226664. Cotranscription of two genes necessary for ribosomal protein L11 methylation (prmA) and pantothenate transport (panF) in Escherichia coli K-12. Vanet A, Plumbridge JA, Alix JH;. J Bacteriol 1993;175:7178-7188. (from Pfam)

Date:

2024-10-16

This domain is found in ribosomal RNA small subunit methyltransferase C (eg Swiss:P44453) as well as other methyltransferases (eg Swiss:Q53742). (from Pfam)

Date:

2024-08-14

This domain is the methyltransferase domain found in ribosomal RNA large subunit methyltransferase K/L from Escherichia coli (RmlKL), tRNA (guanine(10)-N2)-dimethyltransferase from Methanocaldococcus jannaschii and similar proteins, which have a THUMP domain at the N-terminal [1-4]. [1]. 11295541. THUMP - a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases. Aravind L, Koonin EV;. Trends Biochem Sci 2001;26:215-217. [2]. 16343540. Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain. Waterman DG, Ortiz-Lombardia M, Fogg MJ, Koonin EV, Antson AA;. J Mol Biol. 2006;356:97-110. [3]. 17010378. Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. Lesnyak DV, Sergiev PV, Bogdanov AA, Dontsova OA;. J Mol Biol. 2006;364:20-25. [4]. 22362734. Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA. Wang KT, Desmolaize B, Nan J, Zhang XW, Li LF, Douthwaite S, Su XD;. Nucleic Acids Res. 2012;40:5138-5148. (from Pfam)

Date:

2024-10-16