Protein Family Models

This entry represents a mainly helical domain found in flagellar hook-associated protein FlgK and related proteins. FlgK is one of three hook associated proteins that form the hook-filament junction. This domain adopts a broken antiparallel helical bundle comprising six helical segments [1-2]. Paper describing PDB structure 4ut1. [1]. 25645451. From crystal structure to in silico epitope discovery in the Burkholderia pseudomallei flagellar hook-associated protein FlgK. Gourlay LJ, Thomas RJ, Peri C, Conchillo-Sole O, Ferrer-Navarro M, Nithichanon A, Vila J, Daura X, Lertmemongkolchai G, Titball R, Colombo G, Bolognesi M;. FEBS J. 2015;282:1319-1333. Paper describing PDB structure 5xbj. [2]. 29147015. Structure of FlgK reveals the divergence of the bacterial Hook-Filament Junction of Campylobacter. Bulieris PV, Shaikh NH, Freddolino PL, Samatey FA;. Sci Rep. 2017;7:15743. (from Pfam)

Date:

2024-10-29

This family consists of a number of C-terminal domains of unknown function. This domain seems to be specific to flagellar basal-body rod and flagellar hook proteins in which Pfam:PF00460 is often present at the extreme N terminus. [1]. 2129540. FlgB, FlgC, FlgF and FlgG. A family of structurally related proteins in the flagellar basal body of Salmonella typhimurium. Homma M, Kutsukake K, Hasebe M, Iino T, Macnab RM;. J Mol Biol. 1990;211:465-477. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

The flagellar hook-associated protein FlgK of bacterial flagella has conserved N- and C-terminal domains. The central region is highly variable in length and sequence, and often contains substantial runs of low-complexity sequence. This model is built from an alignment of FlgK sequences with the central region excised. Note that several other proteins of the flagellar apparatus also are homologous in the N- and C-terminal regions to FlgK, but are excluded from this model.

Gene:

flgK

Date:

2024-06-24