Protein Family Models

This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is about 250 amino acids in length. This domain is found associated with Pfam:PF00884. (from Pfam)

Date:

2024-08-14

This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars [1]. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity [4]. The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum [2]. [1]. 9344668. Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes. Jin-Hua P, Goding JW, Nakamura H, Sano K;. Genomics 1997;45:412-415. [2]. 8617788. Cloning and expression of the unique Ca2+-ATPase from Flavobacterium odoratum. Peiffer WE, Desrosiers MG, Menick DR;. J Biol Chem 1996;271:5095-5100. [3]. 7730366. Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. Deissler H, Lottspeich F, Rajewsky MF;. J Biol Chem 1995;270:9849-9855. [4]. 7982964. cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. Murata J, Lee HY, Clair T, Krutzsch HC, Arestad AA, Sobel ME, Liotta LA, Stracke ML;. J Biol Chem 1994;269:30479-30484. (from Pfam)

Date:

2024-10-16

Date:

2024-08-14

DUF3413 domain-containing protein with an alkaline phosphatase/sulfatase domain, similar to Salmonella enterica membrane-anchored periplasmic protein YejM

Date:

2017-02-03