Protein Family Models

Species that include Porphyromonas gingivalis, Fibrobacter succinogenes, Flavobacterium johnsoniae, Cytophaga hutchinsonii, Gramella forsetii, Prevotella intermedia, and Salinibacter ruber have on average twenty or more copies of this C-terminal domain, associated with sorting to the outer membrane and covalent modification. This domain targets proteins to type IX secretion systems and is secreted then cleaved off by a C-terminal signal peptidease [2]. Based on similarity to other families it is likely that this domain adopts an immunoglobulin like fold. [1]. 24007199. Protein substrates of a novel secretion system are numerous in. the Bacteroidetes phylum and have in common a cleavable. C-terminal secretion signal, extensive post-translational. modification, and cell-surface attachment.. Veith PD, Nor Muhammad NA, Dashper SG, Likic VA, Gorasia DG,. Chen D, Byrne SJ, Catmull DV, Reynolds EC;. J Proteome Res. 2013;12:4449-4461.. [2]. 22593568. PG0026 is the C-terminal signal peptidase of a novel secretion. system of Porphyromonas gingivalis.. Glew MD, Veith PD, Peng B, Chen YY, Gorasia DG, Yang Q, Slakeski. N, Chen D, Moore C, Crawford S, Reynolds EC;. J Biol Chem. 2012;287:24605-24617. (from Pfam)

Date:

2024-08-14

T9SS type A sorting domain-containing protein may function in protein secretion; the conserved C-terminal domain functions as an outer membrane translocation signal for export of virulence factors to the cell surface

Date:

2022-08-29

Type IX secretions systems (T9SS) occur in the Bacteroidetes, such as Cytophaga hutchinsonii and Flavobacterium johnsoniae, and are required for the type of gliding motility seen in that lineage, although they are not limited processing target proteins from that system. The C-terminal domain described by TIGR04183, recognized as sorting signal by T9SS, is now known as type A, and is quite distinct from type B (see TIGR04131). Most targets of T9SS are cleaved by a transpeptidase and then attached to a component of the outer membrane, but a few are released in soluble form.

Date:

2023-07-13