Protein Family Models

This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B. (from Pfam)

Date:

2024-08-14

This entry represents the C-terminal domain of the bacterial DNA helicase TraI (EC:3.6.1.-). TraI is a bifunctional protein that catalyses the unwinding of duplex DNA as well as acts as a sequence-specific DNA trans-esterase, providing the site- and strand-specific nick required to initiate DNA transfer [1]. This domain is essential for conjugative DNA transfer [2]. [1]. 11054423. F plasmid conjugative DNA transfer: the TraI helicase activity is essential for DNA strand transfer. Matson SW, Sampson JK, Byrd DR;. J Biol Chem 2001;276:2372-2379. [2]. 19136009. A novel fold in the TraI relaxase-helicase c-terminal domain is essential for conjugative DNA transfer. Guogas LM, Kennedy SA, Lee JH, Redinbo MR;. J Mol Biol. 2009;386:554-568. [3]. 28457609. Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial Conjugation. Ilangovan A, Kay CWM, Roier S, El Mkami H, Salvadori E, Zechner EL, Zanetti G, Waksman G;. Cell. 2017;169:708-721. (from Pfam)

Date:

2024-10-16