Protein Family Models

This domain is found at the N-terminus of eubacterial magnesium transporters of the MgtE family Pfam:PF01769. This domain is an intracellular domain that has an alpha-helical structure. The crystal structure of the MgtE transporter [1] shows two of 5 magnesium ions are in the interface between the N domain and the CBS domains. In the absence of magnesium there is a large shift between the N and CBS domains. [1]. 17700703. Crystal structure of the MgtE Mg2+ transporter.. Hattori M, Tanaka Y, Fukai S, Ishitani R, Nureki O;. Nature. 2007;448:1072-1075. (from Pfam)

Date:

2024-08-14

CBS domains are small intracellular modules that pair together to form a stable globular domain [2]. This family represents a single CBS domain. Pairs of these domains have been termed a Bateman domain [6]. CBS domains have been shown to bind ligands with an adenosyl group such as AMP, ATP and S-AdoMet [5]. CBS domains are found attached to a wide range of other protein domains suggesting that CBS domains may play a regulatory role making proteins sensitive to adenosyl carrying ligands. The region containing the CBS domains in Cystathionine-beta synthase is involved in regulation by S-AdoMet [4]. CBS domain pairs from AMPK bind AMP or ATP [5]. The CBS domains from IMPDH and the chloride channel CLC2 bind ATP [5]. Discovery and naming of the CBS domain.. [1]. 9020585. The structure of a domain common to archaebacteria and the. homocystinuria disease protein.. Bateman A;. Trends Biochem Sci 1997;22:12-13.. 3D Structure found as a sub-domain in TIM barrel of. inosine-monophosphate dehydrogenase.. [2]. 10200156. Characteristics and crystal structure of bacterial. inosine-5'-monophosphate dehydrogenase.. Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E,. Joachimiak A, Collart FR;. Biochemistry 1999;38:4691-4700.. Discovery of CBS domain.. [3]. 9106071. CBS domains in ClC chloride channels implicated in myotonia and. nephrolithiasis (kidney stones).. Ponting CP;. J Mol Med 1997;75:160-163.. [4]. 11524006. Regulation of human cystathionine beta-synthase by. S-adenosyl-L-methionine: evidence for two catalytically active. conformations involving an autoinhibitory domain in the. C-terminal region.. Janosik M, Kery V, . TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

MgtE family magnesium transporter is involved in the maintenance of cellular Mg(2+) homeostasis; contains a PRC-barrel domain

Date:

2021-01-08