Protein Family Models

ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralised by the antitoxin ParD. The family also encompasses RelE/ParE described in [2]. [1]. 1459960. Definition of a minimal plasmid stabilization system from the broad-host-range plasmid RK2. Roberts RC, Helinski DR;. J Bacteriol 1992;174:8119-8132. [2]. 14659018. New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. Anantharaman V, Aravind L;. Genome Biol 2003;4:R81. [3]. 20487277. Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Fiebig A, Castro Rojas CM, Siegal-Gaskins D, Crosson S;. Mol Microbiol. 2010;77:236-251. (from Pfam)

Date:

2024-10-16

Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all are found adjacent to RelB/DinJ family antitoxin genes (TIGR02384), as are most genes found by the resulting model. StbE from Morganella morganii plasmid R485 shows typical behaviour for an addiction module toxin. It cannot be cloned without its partner (the antitoxin), whereas its partner cannot confer plasmid stability without StbE.

Date:

2019-09-10

type II toxin-antitoxin (TA) system RelE/ParE family toxin is the RelE/ParE-like toxin component of a type II toxin-antitoxin system, its activity is attenuated by interaction with its cognate antitoxin

Date:

2024-07-10