Protein Family Models for Protein (Select 1535637474) - Protein Family Models

Select item 4272001.

winged helix-turn-helix transcriptional regulator

Date:: 2024-08-14

Family Accession:: NF024804.5
Method:: HMM

Select item 4236352.

AsnC family transcriptional regulator

GO Terms:

Molecular Function:: sequence-specific DNA binding (GO:0043565)

Date:: 2024-08-14

Family Accession:: NF024796.5
Method:: HMM

Select item 4216993.

MarR family transcriptional regulator

The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds [1]. The structure of MarR is known [2] and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif. [1]. 9068629. The Salmonella typhimurium mar locus: molecular and genetic. analyses and assessment of its role in virulence.. Sulavik MC, Dazer M, Miller PF;. J Bacteriol 1997;179:1857-1866.. [2]. 11473263. The crystal structure of MarR, a regulator of multiple. antibiotic resistance, at 2.3 A resolution.. Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF;. Nat Struct Biol 2001;8:710-714. (from Pfam)

GO Terms:

Molecular Function:: DNA-binding transcription factor activity (GO:0003700)

Biological Process:: regulation of DNA-templated transcription (GO:0006355)

Date:: 2024-08-14

Family Accession:: NF024212.5
Method:: HMM

Select item 4182084.

HTH domain-containing protein

This family includes helix-turn-helix domains in a wide variety of proteins. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF019884.5
Method:: HMM

Select item 4114295.

Lrp/AsnC ligand binding domain-containing protein

The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold [2]. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). [1]. 7770911. The eubacterial transcriptional activator Lrp is present in the. archaeon Pyrococcus furiosus.. Kyrpides NC, Ouzounis CA;. Trends Biochem Sci 1995;20:140-141.. [2]. 17374605. The structure and transcriptional analysis of a global regulator. from Neisseria meningitidis.. Ren J, Sainsbury S, Combs SE, Capper RG, Jordan PW, Berrow NS,. Stammers DK, Saunders NJ, Owens RJ;. J Biol Chem. 2007;282:14655-14664. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF013224.5
Method:: HMM

Select item 4029596.