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HU domain fused to wHTH, Ig, or Glycine-rich motif
Rapidly-diverging family of HU domains predominantly observed in the bacteroidetes lineage with a predicted role in recognition and possible interception of the DNA of parasitic elements, a counter-conflict strategy preventing incorporation of these elements into the host genome [1]. [1]. 28441108. Novel clades of the HU/IHF superfamily point to unexpected roles in the eukaryotic centrosome, chromosome partitioning, and biologic conflicts. Burroughs AM, Kaur G, Zhang D, Aravind L;. Cell Cycle. 2017;16:1093-1103. (from Pfam)
HU family DNA-binding protein
integration host factor subunit beta
integration host factor is involved in condensation of the bacterial nucleoid and in regulation of a variety of cellular functions such as DNA replication and transcription
One of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control
This protein forms a site-specific DNA-binding heterodimer with the homologous integration host factor alpha subunit. It is closely related to the DNA-binding protein HU.
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