Protein Family Models

An uncharacterized alpha+beta fold domain that is mostly fused to a RimK-like ATP-grasp and is found in bacteria and euryarchaea. Members of this family are almost always associated in gene neighborhoods with a GNAT-like acetyltransferase fused to a papain-like petidase. Additionally M20-like peptidases, GCS2, 4Fe-4S Ferredoxins, a distinct metal-sulfur cluster protein and ribosomal proteins are found in the gene neighborhoods. Contextual analysis suggests a role for these in peptide biosynthesis [1]. [1]. 20023723. Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins. Iyer LM, Abhiman S, Maxwell Burroughs A, Aravind L;. Mol Biosyst. 2009;5:1636-1660. (from Pfam)

Date:

2024-10-16

RimK family protein containing a C-terminal domain similar to ribosomal protein S6--L-glutamate ligase RimK that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6

Date:

2019-05-23