Protein Family Models

Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by bacterial adenylyl/guanylyl cyclase domains. The sensing of ligands by AGS-C is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers [1]. [1]. 26590262. Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling. Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;. Nucleic Acids Res. 2015;43:10633-10654. (from Pfam)

Date:

2024-11-19

Nucleotide synthetase enzyme of the DNA polymerase beta superfamily. Experimental studies have demonstrated cGAMP synthetase activity in the Vibrio cholerae DncV protein, a member of the SMODS family. The diversity inherent to the SMODS family suggests members of the family could generate a range of nucleotides, cyclic and/or linear. The nucleotide second messengers generated by the SMODS domains are predicted to activate effectors in a class of conflict systems reliant on the production and sensing of the nucleotide second messengers [1] [2]. [1]. 26590262. Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling. Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;. Nucleic Acids Res. 2015;43:10633-10654. [2]. 22500802. Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence. Davies BW, Bogard RW, Young TS, Mekalanos JJ;. Cell. 2012;149:358-370. (from Pfam)

Date:

2024-11-04