Protein Family Models

This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions [2]. This family also includes Swiss:Q9Y2Q5 Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus Swiss:Q50883, a protein involved in gliding motility [4]. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role. [1]. 11416132. Site-specific recognition of a 70-base-pair element containing d(GA)(n) repeats mediates bithoraxoid polycomb group response element-dependent silencing. Hodgson JW, Argiropoulos B, Brock HW;. Mol Cell Biol 2001;21:4528-4543. [2]. 10402468. Drosophila roadblock and Chlamydomonas LC7: a conserved family of dynein-associated proteins involved in axonal transport, flagellar motility, and mitosis. Bowman AB, Patel-King RS, Benashski SE, McCaffery JM, Goldstein LS, King SM;. J Cell Biol 1999;146:165-180. This paper shows the relationship of this family to the MglB family. [3]. 11084347. Dynein light chains of the Roadblock/LC7 group belong to an ancient protein superfamily implicated in NTPase regulation. Koonin EV, Aravind L;. Curr Biol 2000;10:774-776. [4]. 2464581. Gliding motility in Myxococcus xanthus: mgl locus, RNA, and predicted protein products. Stephens K, Hartzell P, Kaiser D;. J Bacteriol 1989;171:819-830. (from Pfam)

Date:

2024-10-16

roadblock/LC7 domain-containing protein such as Trichoplax sp. H2 ragulator complex protein LAMTOR2

Date:

2024-08-29