Protein Family Models

Date:

2024-08-14

This entry represents a wide variety of bacterial Ig domains. [1]. 21606337. Structure of a bacterial cell surface decaheme electron conduit. Clarke TA, Edwards MJ, Gates AJ, Hall A, White GF, Bradley J, Reardon CL, Shi L, Beliaev AS, Marshall MJ, Wang Z, Watmough NJ, Fredrickson JK, Zachara JM, Butt JN, Richardson DJ;. Proc Natl Acad Sci U S A. 2011;108:9384-9389. (from Pfam)

Date:

2024-10-16

This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins. (from Pfam)

Date:

2024-08-14

A domain of unknown function found in multiple copies in several archaebacterial proteins. Conserved N-terminal lysine and C-terminal asparagine with central asp/glu suggests that many of these domain may contain an isopeptide bond. In Methanothermobacter sp. CaT2, a DUF11-containing repeat hypothetical protein encoded by MTCT_1020 plays a key role as a membrane-bound adhesion protein in the aggregation of CaT2. DUF11-containing repeat domains are not involved in aggregation, but may be important for stabilizing the surface cell wall structures of CaT2 [1]. [1]. 31189768. An Aggregation-defective Mutant of Methanothermobacter sp. CaT2 Reveals Unique Protein-dependent Aggregation. Sumikawa K, Kosaka T, Mayahara N, Matsutani M, Udo K, Yamada M;. Microbes Environ. 2019;34:244-251. (from Pfam)

Date:

2024-10-16

This model represents the conserved region of about 53 amino acids shared between regions, usually repeated, of proteins from a small number of phylogenetically diverse prokaryotes. The model overlaps significantly in coverage with DUF11 (PF01345). Examples of the domain occur within longer repeats in three of the five longest proteins of Bacillus anthracis, in a 131-residue repeat in a cell wall-anchored protein of Enterococcus faecalis, and a 120-residue repeat in Methanobacterium thermoautotrophicum. A similar region is found in some Chlamydial outer membrane proteins.

Date:

2021-07-15

This domain of about 100 residues was found originally in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion. This HMM for a repeated domain overlaps substantially (shifted by half its length) with newer Pfam model PF17803 (bacterial cadherin-like domain).

Date:

2020-10-24

This 95-amino acid repeat occurs in tandem in proteins that may be several thousand amino acids long.

Date:

2020-10-26