Protein Family Models

Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by bacterial adenylyl/guanylyl cyclase domains. The sensing of ligands by AGS-C is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers [1]. [1]. 26590262. Comparative genomic analyses reveal a vast, novel network of. nucleotide-centric systems in biological conflicts, immunity and. signaling.. Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;. Nucleic Acids Res. 2015;43:10633-10654. (from Pfam)

Date:

2024-08-14

Predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains [1]. This domain has been characterised in CD-NTase-associated protein 4 (Cap4), the founding member of a major family of downstream receptors that specifically respond to nucleotide second messenger signals in CBASS immunity, a bacterial system that provides immunity against bacteriophage [2,3]. SAVED exhibits divergence in its nucleotide binding pocket which enables the recognition of a wide range of CD-NTase products such as bacterial second messengers with alternative ring size, nucleobase, and 3'-5' or 2'-5' phosphodiester linkages [2]. The sensing of ligands by SAVED activates effectors that are essential for CBASS-mediated protection of bacteria from phage infection. [1]. 26590262. Comparative genomic analyses reveal a vast, novel network of. nucleotide-centric systems in biological conflicts, immunity and. signaling.. Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;. Nucleic Acids Res. 2015;43:10633-10654.. [2]. 32544385. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and. 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria. from Phage Infection.. Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT,. Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F,. Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ;. Cell. 2020; [Epub ahead of print]. [3]. 32839535. Diversity and classification of cyclic-oligonucleotide-based. anti-phage signalling systems.. Millman A, Melamed S, Amitai G, Sorek R;. Nat Microbiol. 2020;5:1608-1615. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Nucleotide synthetase enzyme of the DNA polymerase beta superfamily. Experimental studies have demonstrated cGAMP synthetase activity in the Vibrio cholerae DncV protein, a member of the SMODS family. The diversity inherent to the SMODS family suggests members of the family could generate a range of nucleotides, cyclic and/or linear. The nucleotide second messengers generated by the SMODS domains are predicted to activate effectors in a class of conflict systems reliant on the production and sensing of the nucleotide second messengers [1] [2]. [1]. 26590262. Comparative genomic analyses reveal a vast, novel network of. nucleotide-centric systems in biological conflicts, immunity and. signaling.. Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;. Nucleic Acids Res. 2015;43:10633-10654.. [2]. 22500802. Coordinated regulation of accessory genetic elements produces. cyclic di-nucleotides for V. cholerae virulence.. Davies BW, Bogard RW, Young TS, Mekalanos JJ;. Cell. 2012;149:358-370. (from Pfam)

Date:

2024-08-14

The SAVED (SMODS-Associated and fused to Various Effector Domains) domain is predicted to function as a sensor domain, sensing nucleotides or nucleotide derivatives generated by SMODS and other nucleotide synthetase domains. The sensing of ligands by SAVED is predicted to activate effectors deployed by a class of conflict systems which are reliant on the on the production and sensing of the nucleotide second messengers.

Date:

2021-01-21