Protein Family Models

Date:

2024-08-14

calcium-binding protein such as serralysin, an M10 family metallopeptidase that contains a glycine-rich C-terminal domain Gly-Gly-Xaa-Gly-Asn-Asp which has a role in binding calcium ions| M10 family metallopeptidase similar to serralysin and Pseudomonas aeruginosa alkaline protease, which include an N-terminal peptidase domain and a C-terminal calcium-binding domain

Date:

2017-03-02

This model represents a C-terminal domain associated with secretion by type 1 secretion systems (T1SS). Members of this subclass do not include the RtxA toxin of Vibrio cholerae and its homologs, although the two classes of proteins share large size, occurrence in genomes with T1SS, regions with long tandem repeats, and regions with the glycine-rich repeat modeled by PF00353.

Date:

2021-10-27

This domain of about 100 residues was found originally in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion. This HMM for a repeated domain overlaps substantially (shifted by half its length) with newer Pfam model PF17803 (bacterial cadherin-like domain).

Date:

2020-10-24