Protein Family Models

This is the catalytic helper subdomain found in collagenase G from Clostridium histolyticum. This domain is indispensable for proper folding and full peptidase activity [1, 2]. [1]. 23703618. Structural basis for activity regulation and substrate preference of clostridial collagenases G, H, and T. Eckhard U, Schonauer E, Brandstetter H;. J Biol Chem. 2013;288:20184-20194. [2]. 21947205. Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis. Eckhard U, Schonauer E, Nuss D, Brandstetter H;. Nat Struct Mol Biol. 2011;18:1109-1114. (from Pfam)

Date:

2024-10-16

This domain is found in microbial collagenase metalloproteases to the N-terminus of Pfam:PF01752. (from Pfam)

Date:

2024-08-14

This domain is normally found at the C-terminus of secreted bacterial peptidases. They are not present in the active peptidase. It is possible that they fulfill a similar role to the PKD (Pfam:PF00801) domain, which also are found in this context. Visual analysis suggests that PKD and PPC are distantly related (personal obs:Bateman A, Yeats C). [1]. 12625841. New Knowledge from Old: In silico discovery of novel protein domains in Streptomyces coelicolor. Yeats C, Bentley S, Bateman A;. BMC Microbiol 2003;3:3-3. (from Pfam)

Date:

2024-10-16

This family of enzymes break down collagens. [1]. 7582017. Molecular analysis of an extracellular protease gene from Vibrio parahaemolyticus. Lee CY, Su SC, Liaw RB;. Microbiology 1995;141:2569-2576. [2]. 8282691. Purification and characterization of Clostridium perfringens 120- kilodalton collagenase and nucleotide sequence of the corresponding gene. Matsushita O, Yoshihara K, Katayama S, Minami J, Okabe A;. J Bacteriol 1994;176:149-156. (from Pfam)

Date:

2024-10-16

Members of this family are the collagenase ColA, as found in Bacillus cereus and related species. This virulence factor is a highly efficient degrader of collagen.

Gene:

colA

Date:

2020-09-15